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Anti-DOK1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DOK1 Antibody

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Name:	Anti-DOK1 Antibody See all DOK1 primary antibodies
Description:	Rabbit polyclonal antibody to DOK1
Applications:	E, WB, ICC
Reactivity:	Human
Immunogen:	Raised against a peptide corresponding to amino acids near the carboxy terminus of human DOK1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Function:	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same on ITGB3.
Tissue Specificity:	Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Sequence Similarities:	Belongs to the DOK family. Type A subfamily.
Post-Translational Modification:	Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 1796 Human Omim: 602919 Human SwissProt: Q99704 Human Unigene: 103854 Human
Synonyms:	Docking protein 1 Antibody Docking protein 1 62kD Antibody DOK 1 Antibody DOK1 Antibody DOK1_HUMAN Antibody Downstream of tyrosine kinase 1 Antibody p62(dok) Antibody P62DOK Antibody pp62 Antibody
Information:	Target information shown above is from the UniProt Consortium.