Anti-Dok-1 (R392) Antibody |产品详情|进口试剂采购网

您好，欢迎来到拜力生物网站！请登录注册

我的订单 | 联系我们 | 在线客服QQ：3012681483 | 客服电话：400-968-7988 | 工作时间：08:30-17:30

主营产品： ELISA试剂盒、抗体、补体血清、兔补体、干扰素、小鼠测温仪、进口试剂、Quidel代理、Swant代理、PBL Assay Science代理

所在位置：首页 > 产品中心 > Antibodies > Antibodies产品

订购信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-Dok-1 (R392) Antibody

品牌：Antibodies

货号：

规格：50µl

货期：

立即购买加入购物车

Anti-Dok-1 (R392) Antibody

商品详情参考文献相关资料

Name:	Anti-Dok-1 (R392) Antibody See all Dok1 primary antibodies
Description:	Rabbit polyclonal antibody to Dok-1 (R392)
Specificity:	Dok-1 (R392) pAb detects endogenous levels of Dok-1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 360-408 of Human Dok-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 62 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same on ITGB3.
Tissue Specificity:	Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Sequence Similarities:	Belongs to the DOK family. Type A subfamily.
Post-Translational Modification:	Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 1796?Human Entrez Gene: 13448?Mouse Entrez Gene: 312477?Rat Omim: 602919?Human SwissProt: Q99704?Human SwissProt: P97465?Mouse SwissProt: Q4QQV2?Rat Unigene: 103854?Human Unigene: 156?Mouse Unigene: 117974?Rat
Synonyms:	Docking protein 1 Antibody Docking protein 1 62kD Antibody DOK 1 Antibody DOK1 Antibody DOK1_HUMAN Antibody Downstream of tyrosine kinase 1 Antibody p62(dok) Antibody P62DOK Antibody pp62 Antibody
Information:	Target information shown above is from the UniProt Consortium.