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Anti-DNAJA3 Antibody

品牌：Antibodies

货号：

规格：50µl

货期：

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Anti-DNAJA3 Antibody

商品详情参考文献相关资料

Name:	Anti-DNAJA3 Antibody See all DNAJA3 primary antibodies
Description:	Rabbit polyclonal antibody to DNAJA3.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human DNAJA3.
Protein Length:	480
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
Tissue Specificity:	Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
Post-Translational Modification:	Tyrosine phosphorylated.
Cellular Location:	Mitochondrion matrix. Cytoplasm > Cytosol. Cell junction > Synapse > Postsynaptic cell membrane. Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK.