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Anti-DKK4 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DKK4 Antibody

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Name:	Anti-DKK4 Antibody See all DKK4 primary antibodies
Description:	Rabbit polyclonal antibody to DKK4
Specificity:	The antibody detects endogenous levels of total DKK4 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human dickkopf WNT signaling pathway inhibitor 4
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Function:	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Tissue Specificity:	Expressed in cerebellum, T-cells, esophagus and lung.
Sequence Similarities:	Belongs to the dickkopf family.
Post-Translational Modification:	Appears to be not glycosylated.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 27121?Human GenBank: NP_055235.1?Human Omim: 605417?Human SwissProt: Q9UBT3?Human Unigene: 159311?Human
Synonyms:	Dickkopf 4 Antibody Dickkopf gene 4 Antibody Dickkopf homolog 4 Antibody Dickkopf homolog 4 (Xenopus laevis) Antibody Dickkopf related protein 4 Antibody Dickkopf-4 Antibody Dickkopf-related protein 4 short form Antibody Dickkopf4 Antibody DKK 4 Antibody Dkk-4 Antibody DKK4 Antibody DKK4_HUMAN Antibody hDkk 4 Antibody hDkk-4 Antibody hDkk4 Antibody MGC129562 Antibody MGC129563 Antibody
Information:	Target information shown above is from the UniProt Consortium.