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Anti-DKK1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-DKK1 Antibody

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Name:	Anti-DKK1 Antibody See all DKK1 primary antibodies
Description:	Rabbit polyclonal antibody to DKK1
Specificity:	DKK1 pAb detects endogenous levels of DKK1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human DKK1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 29 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Function:	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Tissue Specificity:	Placenta.
Sequence Similarities:	Belongs to the dickkopf family.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 22943?Human Entrez Gene: 13380?Mouse Entrez Gene: 293897?Rat Omim: 605189?Human SwissProt: O94907?Human SwissProt: O54908?Mouse Unigene: 40499?Human Unigene: 214717?Mouse
Synonyms:	Dickkopf 1 Antibody Dickkopf 1 homolog Antibody Dickkopf 1 like Antibody Dickkopf homolog 1 Antibody Dickkopf like protein 1 Antibody Dickkopf related protein 1 Antibody Dickkopf WNT signaling pathway inhibitor 1 Antibody Dickkopf-1 Antibody Dickkopf-related protein 1 Antibody DKK 1 Antibody Dkk-1 Antibody DKK1 Antibody DKK1_HUMAN Antibody hDkk 1 Antibody hDkk-1 Antibody hDkk1 Antibody mDkk1 Antibody SK Antibody
Information:	Target information shown above is from the UniProt Consortium.