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Anti-Dkk-3 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Dkk-3 Antibody

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Name:	Anti-Dkk-3 Antibody See all Dkk-3 primary antibodies
Description:	Rabbit polyclonal antibody to Dkk-3
Applications:	WB, IF
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 6 and 313 of Dkk-3
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 1XPBS, 1%BSA, 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.

Function:	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Tissue Specificity:	Highest expression in heart, brain, and spinal cord.
Sequence Similarities:	Belongs to the dickkopf family.
Post-Translational Modification:	N- and O-glycosylated.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 27122 Human Omim: 605416 Human SwissProt: Q9UBP4 Human Unigene: 292156 Human
Synonyms:	Dickkopf 3 Antibody Dickkopf 3 homolog Antibody Dickkopf 3 homolog (Xenopus laevis) Antibody Dickkopf homolog 3 Antibody Dickkopf related protein 3 Antibody Dickkopf related protein 3 Precursor Antibody Dickkopf WNT signaling pathway inhibitor 3 Antibody Dickkopf, Xenopus, homolog of, 3 Antibody Dickkopf-3 Antibody Dickkopf-related protein 3 Antibody Dickkopf3 Antibody DKK 3 Antibody Dkk-3 Antibody Dkk3 Antibody DKK3_HUMAN Antibody hDkk 3 Antibody hDkk-3 Antibody hDkk3 Antibody Regulated in glioma Antibody REIC Antibody RIG Antibody RIG-like 5-6 Antibody RIG-like 7-1 Antibody
Information:	Target information shown above is from the UniProt Consortium.