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Anti-DIL-2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-DIL-2 Antibody

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Overview

Name:	Anti-DIL-2 Antibody See all DIL-2 primary antibodies
Description:	Rabbit polyclonal antibody to DIL-2
Specificity:	The antibody detects endogenous levels of total DIL-2 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from internal of human DIL-2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Tissue Specificity:	Expressed in lung carcinoma cell lines but not in normal lung tissues.
Sequence Similarities:	Belongs to the TPX2 family.
Cellular Location:	Nucleus. Cytoplasm > Cytoskeleton > Spindle. Cytoplasm > Cytoskeleton > Spindle pole. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
Database Links:	Entrez Gene: 22974?Human Entrez Gene: 72119?Mouse Omim: 605917?Human SwissProt: Q9ULW0?Human SwissProt: A2APB8?Mouse Unigene: 244580?Human Unigene: 407737?Mouse
Synonyms:	C20ORF1 Antibody C20orf2 Antibody Chromosome 20 Open Reading Frame 1 Antibody Differentially expressed in cancerous and non-cancerous lung cells 2 Antibody Differentially expressed in cancerous and noncancerous lung cells 2 Antibody Differentially expressed in lung cells Antibody Differentially expressed in lung cells 2 Antibody DIL 2 Antibody DIL-2 Antibody DIL2 Antibody FLS353 Antibody GD:C20orf1 Antibody HCA 519 Antibody HCA519 Antibody HCTP 4 Antibody HCTP4 Antibody Hepatocellular carcinoma associated antigen 519 Antibody Hepatocellular carcinoma-associated antigen 519 Antibody p100 Antibody Preferentially expressed in colorectal cancer Antibody Protein fls353 Antibody REPP 86 Antibody repp86 Antibody Restricted expression proliferation associated protein 100 Antibody Restricted expression proliferation-associated protein 100 Antibody Targeting protein for Xklp2 Antibody TPX 2 Antibody TPX2 Antibody TPX2 microtubule associated homolog Antibody TPX2 microtubule associated protein homolog Antibody TPX2 microtubule nucleation factor Antibody TPX2_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.