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Anti-DICER1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DICER1 Antibody

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Overview

Name:	Anti-DICER1 Antibody See all DICER1 primary antibodies
Description:	Rabbit polyclonal antibody to DICER1
Specificity:	The antibody detects endogenous levels of total DICER1 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human dicer 1, ribonuclease type III
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.7mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
Involvement in Disease:	Pleuropulmonary blastoma: A rare pediatric intrathoracic neoplasm. The tumor arises from the lung, pleura, or both, and appears to be purely mesenchymal in phenotype. It lacks malignant epithelial elements, a feature that distinguishes it from the classic *****-type pulmonary blastoma. It arises during fetal lung development and is often part of an inherited cancer syndrome. The tumor contain both epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined with benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst walls and form a dense layer beneath the epithelial lining. In a subset of patients, overgrowth of the mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis. Some patients have multilocular cystic nephroma, a benign kidney tumor. Goiter multinodular 1, with or without Sertoli-Leydig cell tumors: A common disorder characterized by nodular overgrowth of the thyroid gland. Some individuals may also develop Sertoli-Leydig cell tumors, usually of the ovary. Rhabdomyosarcoma, embryonal, 2: A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.
Sequence Similarities:	Belongs to the helicase family. Dicer subfamily.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 23405?Human Omim: 606241?Human SwissProt: Q9UPY3?Human Unigene: 738957?Human Unigene: 87889?Human
Synonyms:	DCR Antibody DCR1 Antibody Dicer Antibody Dicer 1 ribonuclease III Antibody Dicer 1 ribonuclease type III Antibody DICER1 Antibody DICER_HUMAN Antibody Double-strand-specific ribonuclease Antibody Endoribonuclease Dicer Antibody Helicase MOI Antibody Helicase with RNase motif Antibody HERNA Antibody KIAA0928 Antibody MNG1 Antibody RMSE2 Antibody
Information:	Target information shown above is from the UniProt Consortium.