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Anti-DDK1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DDK1 Antibody

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Name:	Anti-DDK1 Antibody See all DDK1 primary antibodies
Description:	Rabbit polyclonal antibody to DDK1
Specificity:	The antibody detects endogenous levels of total DDK1 protein.
Applications:	IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human dickkopf WNT signaling pathway inhibitor 1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.2mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Function:	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Tissue Specificity:	Placenta.
Sequence Similarities:	Belongs to the dickkopf family.
Cellular Location:	Secreted.