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Anti-DDIT4 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DDIT4 Antibody

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Overview

Name:	Anti-DDIT4 Antibody See all DDIT4 primary antibodies
Description:	Rabbit polyclonal antibody to DDIT4
Specificity:	The antibody detects endogenous levels of total DDIT4 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Full length fusion protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.5mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.
Tissue Specificity:	Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level).
Sequence Similarities:	Belongs to the DDIT4 family.
Post-Translational Modification:	Phosphorylated by GSK3B; this promotes proteasomal degradation.
Cellular Location:	Mitochondrion. Cytoplasm > Cytosol.
Database Links:	Entrez Gene: 54541?Human Omim: 607729?Human SwissProt: Q9NX09?Human Unigene: 523012?Human
Synonyms:	DDIT4 Antibody DDIT4_HUMAN Antibody Dig2 Antibody DNA damage inducible transcript 4 Antibody DNA damage inducible transcript 4 protein Antibody DNA damage-inducible transcript 4 protein Antibody FLJ20500 Antibody HIF 1 responsive protein RTP801 Antibody HIF 1 responsive RTP801 Antibody HIF-1 responsive protein RTP801 Antibody Protein regulated in development and DNA damage response 1 Antibody REDD-1 Antibody REDD1 Antibody RTP801 Antibody
Information:	Target information shown above is from the UniProt Consortium.