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Anti-DCP1A Antibody

品牌：Antibodies

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规格：100µl

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Anti-DCP1A Antibody

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Name:	Anti-DCP1A Antibody See all DCP1A primary antibodies
Description:	Rabbit polyclonal antibody to DCP1A
Specificity:	The antibody detects endogenous levels of total DCP1A protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to residues near the C terminal of human decapping mRNA 1A
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Function:	Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
Tissue Specificity:	Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
Sequence Similarities:	Belongs to the DCP1 family.
Cellular Location:	Cytoplasm > P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524).
Database Links:	Entrez Gene: 55802?Human Omim: 607010?Human SwissProt: Q9NPI6?Human Unigene: 476353?Human
Synonyms:	DCP1 decapping enzyme homolog A Antibody Dcp1a Antibody DCP1A_HUMAN Antibody Decapping enzyme hDcp1a Antibody Decapping mRNA 1A Antibody HSA275986 Antibody mRNA decapping enzyme 1A Antibody mRNA-decapping enzyme 1A Antibody Nbla00360 Antibody Putative protein product of Nbla00360 Antibody Smad4 interacting transcriptional co activator Antibody Smad4-interacting transcriptional co-activator Antibody SMAD4IP1 Antibody SMIF Antibody Transcription factor SMIF Antibody
Information:	Target information shown above is from the UniProt Consortium.