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Anti-DAPK2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DAPK2 Antibody

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Overview

Name:	Anti-DAPK2 Antibody See all DAPK2 primary antibodies
Description:	Rabbit polyclonal antibody to DAPK2
Specificity:	DAPK2 has no cross responses to DAPK1.
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a peptide corresponding to amino acids near the carboxy terminus of human DAPK2. The sequence of. This antigenic peptide is identical to the corresponding amino acids of mouse origin (1,2).
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421).
Tissue Specificity:	Expressed in peritubular interstitial cells of the renal cortex (PubMed:24906443). Isoform 1 is found in the ***** brain while isoform 2 is expressed in brains of embryos and young mice (at protein level) (PubMed:21408167).
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Post-Translational Modification:	Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors.
Cellular Location:	Cytoplasm. Cytoplasmic vesicle > Autophagosome lumen.
Database Links:	Entrez Gene: 23604?Human Entrez Gene: 13143?Mouse Entrez Gene: 300799?Rat Omim: 604727?Human SwissProt: Q9UIK4?Human SwissProt: Q8VDF3?Mouse Unigene: 237886?Human Unigene: 304472?Mouse Unigene: 335252?Mouse Unigene: 98325?Rat
Synonyms:	DAK2 Antibody DAP Kinase 2 Antibody DAP kinase related protein 1 Antibody DAP kinase related protein 1 beta isoform Antibody DAP-kinase-related protein 1 Antibody DAPK2 Antibody DAPK2_HUMAN Antibody Death associated protein kinase 2 Antibody Death-associated protein kinase 2 Antibody DRP 1 Antibody DRP-1 Antibody DRP1 Antibody MGC119312 Antibody
Information:	Target information shown above is from the UniProt Consortium.