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Anti-DACH1 Antibody

品牌：Antibodies

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规格：100µg

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Anti-DACH1 Antibody

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Name:	Anti-DACH1 Antibody See all DACH1 primary antibodies
Description:	Goat polyclonal antibody to DACH1.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human DACH1 (internal region).
Sequence:	SPVENTPQNNECK
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).
Tissue Specificity:	Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
Sequence Similarities:	Belongs to the DACH/dachshund family.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 1602 Human Omim: 603803 Human SwissProt: Q9UI36 Human Unigene: 129452 Human
Synonyms:	DACH Antibody DACH1 Antibody DACH1_HUMAN Antibody Dachshund family transcription factor 1 Antibody Dachshund homolog 1 Antibody dachshund homolog 1 (Drosophila) Antibody Dachsund homolog 1 Antibody FLJ10138 Antibody OTTHUMP00000018494 Antibody
Information:	Target information shown above is from the UniProt Consortium.