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Anti-DACH1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-DACH1 Antibody

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Name:	Anti-DACH1 Antibody See all DACH1 primary antibodies
Description:	Rabbit polyclonal antibody to DACH1.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human DACH1.
Protein Length:	758 (708)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).
Tissue Specificity:	Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
Sequence Similarities:	Belongs to the DACH/dachshund family.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 1602?Human Entrez Gene: 13134?Mouse Omim: 603803?Human SwissProt: Q9UI36?Human SwissProt: Q9QYB2?Mouse Unigene: 129452?Human Unigene: 320593?Mouse
Synonyms:	DACH Antibody DACH1 Antibody DACH1_HUMAN Antibody Dachshund family transcription factor 1 Antibody Dachshund homolog 1 Antibody dachshund homolog 1 (Drosophila) Antibody Dachsund homolog 1 Antibody FLJ10138 Antibody OTTHUMP00000018494 Antibody
Information:	Target information shown above is from the UniProt Consortium.