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Anti-Cytokeratin 18 Antibody

品牌：Antibodies

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规格：100µg

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Anti-Cytokeratin 18 Antibody

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Overview

Name:	Anti-Cytokeratin 18 Antibody See all Cytokeratin 18 primary antibodies
Description:	Mouse monoclonal (DC-10) antibody to Cytokeratin 18 (FITC).
Specificity:	The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.
Applications:	IP, WB, IHC-P, ICC, ELISA, FC
Reactivity:	Human
Immunogen:	Human breast carcinoma cell line PMC-42.
Host:	Mouse
Clonality:	Monoclonal
Clone:	DC-10
Isotype:	IgG1
Conjugate:	FITC
Concentration:	0.1 mg/ml
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage:	Store in the dark at 2-8°C. Avoid prolonged exposure to light.

Target

Function:	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Tissue Specificity:	Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Involvement in Disease:	Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequence Similarities:	Belongs to the intermediate filament family.
Post-Translational Modification:	Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Cellular Location:	Cytoplasm > Perinuclear region. Nucleus > Nucleolus.
Database Links:	Entrez Gene: 3875?Human Omim: 148070?Human SwissProt: P05783?Human Unigene: 406013?Human
Synonyms:	Cell proliferation inducing gene 46 protein Antibody Cell proliferation inducing protein 46 Antibody Cell proliferation-inducing gene 46 protein Antibody CK 18 Antibody CK-18 Antibody CK18 Antibody CYK 18 Antibody CYK18 Antibody Cytokeratin 18 Antibody Cytokeratin endo B Antibody Cytokeratin-18 Antibody K 18 Antibody K18 Antibody K1C18_HUMAN Antibody KA18 Antibody Keratin 18 Antibody Keratin 18, type I Antibody Keratin D Antibody keratin, type I cytoskeletal 18 Antibody Keratin-18 Antibody Krt18 Antibody
Information:	Target information shown above is from the UniProt Consortium.