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Anti-Cytokeratin 17 Antibody

品牌：Antibodies

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规格：50µl

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Anti-Cytokeratin 17 Antibody

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Overview

Name:	Anti-Cytokeratin 17 Antibody See all Cytokeratin 17 primary antibodies
Description:	Rabbit polyclonal antibody to Cytokeratin 17
Specificity:	Cytokeratin 17 pAb detects endogenous levels of Cytokeratin 17 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human Cytokeratin 17.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 48 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Tissue Specificity:	Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
Involvement in Disease:	Pachyonychia congenita 2: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth. Steatocystoma multiplex: Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
Sequence Similarities:	Belongs to the intermediate filament family.
Post-Translational Modification:	Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 3872?Human Entrez Gene: 16667?Mouse Entrez Gene: 287702?Rat Omim: 148069?Human SwissProt: Q04695?Human SwissProt: Q9QWL7?Mouse SwissProt: Q6IFU8?Rat Unigene: 2785?Human Unigene: 14046?Mouse Unigene: 106755?Rat
Synonyms:	39.1 Antibody CK 17 Antibody CK-17 Antibody Cytokeratin 17 Antibody Cytokeratin-17 Antibody K17 Antibody K1C17_HUMAN Antibody Keratin Antibody Keratin 17 Antibody keratin 17 epitope S1 Antibody keratin 17 epitope S2 Antibody keratin 17 epitope S4 Antibody Keratin 17, type I Antibody Keratin type I cytoskeletal 17 Antibody keratin, type i cytoskeletal 17 [version 1] Antibody Keratin-17 Antibody KRT17 Antibody PC Antibody PC2 Antibody PCHC1 Antibody type I cytoskeletal 17 Antibody
Information:	Target information shown above is from the UniProt Consortium.