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Anti-CYTH2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CYTH2 Antibody

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Overview

Name:	Anti-CYTH2 Antibody See all CYTH2 primary antibodies
Description:	Rabbit polyclonal antibody to CYTH2.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CYTH2.
Protein Length:	400
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth (By similarity).
Tissue Specificity:	Widely expressed.
Cellular Location:	Cell membrane. Cytoplasm. Cell projection. Cell projection > Growth cone. Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to plasma membrane (PubMed:17398095). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas.
Database Links:	Entrez Gene: 9266?Human Entrez Gene: 19158?Mouse Entrez Gene: 116692?Rat Omim: 602488?Human SwissProt: Q99418?Human SwissProt: P63034?Mouse SwissProt: P63035?Rat Unigene: 144011?Human Unigene: 272130?Mouse Unigene: 3732?Rat
Synonyms:	ARF exchange factor Antibody ARF nucleotide opener Antibody ARF nucleotide- opener Antibody Arno Antibody ARNO protein Antibody CLM2 Antibody CTS18 Antibody CTS18.1 Antibody CYH2_HUMAN Antibody Cyth2 Antibody Cytohesin 2 Antibody Cytohesin-2 Antibody MGC137537 Antibody MGC80440 Antibody PH Antibody PH, SEC7 and coiled-coil domain-containing protein 2 Antibody Pleckstrin homology Sec7 and coiled coil domains 2 Antibody Pleckstrin homology Sec7 and coiled coil domains protein 2 Antibody Protein ARNO Antibody PSCD2 Antibody PSCD2L Antibody PSCD2L, formerly Antibody Sec7 Antibody SEC7 and coiled-coil domain-containing protein 2 Antibody SEC7 homolog B Antibody Sec7B Antibody SEC7L Antibody Sec7p L Antibody Sec7p-like Antibody Sec7pL Antibody
Information:	Target information shown above is from the UniProt Consortium.