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Anti-CYR61 Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-CYR61 Antibody

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Name:	Anti-CYR61 Antibody See all CYR61 primary antibodies
Description:	Rabbit polyclonal antibody to CYR61
Specificity:	The antibody detects endogenous levels of total CYR61 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human cysteine-rich, angiogenic inducer, 61
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.6mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Function:	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Sequence Similarities:	Belongs to the CCN family.
Cellular Location:	Secreted.