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Anti-CYP19A1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CYP19A1 Antibody

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Overview

Name:	Anti-CYP19A1 Antibody See all CYP19A1 primary antibodies
Description:	Rabbit polyclonal antibody to CYP19A1
Specificity:	CYP19A1 Polyclonal Antibody detects endogenous levels of CYP19A1 protein.
Applications:	WB, IHC, IF, ELISA
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from the Internal region of human CYP19A1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Tissue Specificity:	Widely expressed, including in ***** and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.
Involvement in Disease:	Aromatase excess syndrome: An autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females. Aromatase deficiency: A rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In ***** females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
Sequence Similarities:	Belongs to the cytochrome P450 family.
Post-Translational Modification:	Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1).
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 1588?Human Entrez Gene: 13075?Mouse Entrez Gene: 25147?Rat Omim: 107910?Human SwissProt: P11511?Human SwissProt: P28649?Mouse SwissProt: P22443?Rat Unigene: 260074?Human Unigene: 478781?Mouse Unigene: 5199?Mouse Unigene: 21402?Rat
Synonyms:	ARO Antibody ARO1 Antibody Aromatase Antibody CP19A_HUMAN Antibody CPV1 Antibody CYAR Antibody CYP19 Antibody Cyp19a1 Antibody CYPXIX Antibody Cytochrome P-450AROM Antibody Cytochrome P450 19A1 Antibody Cytochrome P450, family 19, subfamily A, polypeptide 1 Antibody Cytochrome P450, subfamily XIX (aromatization of androgens) Antibody Estrogen synthase Antibody Estrogen synthetase Antibody Flavoprotein linked monooxygenase Antibody MGC104309 Antibody Microsomal monooxygenase Antibody OTTHUMP00000162543 Antibody OTTHUMP00000198350 Antibody P 450AROM Antibody
Information:	Target information shown above is from the UniProt Consortium.