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Anti-CYP17A1 (N249) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CYP17A1 (N249) Antibody

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Overview

Name:	Anti-CYP17A1 (N249) Antibody See all CYP17A1 primary antibodies
Description:	Rabbit polyclonal antibody to CYP17A1 (N249)
Specificity:	CYP17A1 (N249) pAb detects endogenous levels of CYP17A1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 211-260 of Human CYP17A1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 57 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Involvement in Disease:	Adrenal hyperplasia 5: A form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short ***** stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH) and 'cryptic' (asymptomatic).
Sequence Similarities:	Belongs to the cytochrome P450 family.
Post-Translational Modification:	Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 1586?Human Entrez Gene: 13074?Mouse Entrez Gene: 25146?Rat Omim: 609300?Human SwissProt: P05093?Human SwissProt: P27786?Mouse SwissProt: P11715?Rat Unigene: 438016?Human Unigene: 1262?Mouse Unigene: 10172?Rat
Synonyms:	20 lyase Antibody CP17A_HUMAN Antibody CPT7 Antibody CYP17 Antibody CYP17A1 Antibody CYPXVII Antibody Cytochrome P450 17A1 Antibody Cytochrome P450 family 17 Antibody Cytochrome P450 family 17 subfamily A polypeptide 1 Antibody Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia Antibody Cytochrome p450 XVIIA1 Antibody Cytochrome P450-C17 Antibody Cytochrome P450c17 Antibody OTTHUMP00000020382 Antibody P450 C17 Antibody P450c17 Antibody S17AH Antibody Steroid 17 alpha hydroxylase/17,20 lyase Antibody Steroid 17 alpha monooxygenase Antibody Steroid 17-alpha-hydroxylase/17 Antibody Steroid 17-alpha-monooxygenase Antibody
Information:	Target information shown above is from the UniProt Consortium.