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Anti-CYP11B1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CYP11B1 Antibody

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Overview

Name:	Anti-CYP11B1 Antibody See all CYP11B1 primary antibodies
Description:	Rabbit polyclonal antibody to CYP11B1
Specificity:	The antibody detects endogenous levels of total CYP11B1 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to residues near the C terminal of human cytochrome P450, family 11, subfamily B, polypeptide 1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Involvement in Disease:	Adrenal hyperplasia 4: A form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short ***** stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH) and 'cryptic' (asymptomatic). Hyperaldosteronism, familial, 1: A disorder characterized by hypertension, variable hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol. There is significant phenotypic heterogeneity, and some individuals never develop hypertension.
Sequence Similarities:	Belongs to the cytochrome P450 family.
Cellular Location:	Mitochondrion membrane.
Database Links:	Entrez Gene: 1584?Human Omim: 610613?Human SwissProt: P15538?Human Unigene: 184927?Human
Synonyms:	CPN1 Antibody CYP11B Antibody CYP11B1 Antibody CYPXIB1 Antibody Cytochrome P 450c11 Antibody Cytochrome P450 11B1, mitochondrial Antibody Cytochrome p450 XIB1 Antibody Cytochrome P450, family 11, subfamily B, polypeptide 1 Antibody Cytochrome P450, subfamily XIB (steroid 11 beta hydroxylase), polypeptide 1 Antibody Cytochrome P450, subfamily XIB, polypeptide 1 Antibody Cytochrome P450C11 Antibody FHI Antibody P 450C11 Antibody P450C11 Antibody S11BH Antibody Steroid 11 beta hydroxylase Antibody Steroid 11 beta monooxygenase Antibody
Information:	Target information shown above is from the UniProt Consortium.