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Anti-CYP11A1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CYP11A1 Antibody

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Overview

Name:	Anti-CYP11A1 Antibody See all CYP11A1 primary antibodies
Description:	Rabbit polyclonal antibody to CYP11A1
Specificity:	The antibody detects endogenous level of total CYP11A1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CYP11A1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Involvement in Disease:	Adrenal insufficiency, congenital, with 46,XY sex reversal: A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia.
Sequence Similarities:	Belongs to the cytochrome P450 family.
Cellular Location:	Mitochondrion membrane.
Database Links:	Entrez Gene: 1583?Human Entrez Gene: 13070?Mouse Entrez Gene: 29680?Rat Omim: 118485?Human SwissProt: P05108?Human SwissProt: Q9QZ82?Mouse SwissProt: P14137?Rat Unigene: 303980?Human Unigene: 302865?Mouse Unigene: 1401?Rat
Synonyms:	Cholesterol 20 22 desmolase Antibody Cholesterol desmolase Antibody Cholesterol monooxygenase (side chain cleaving) Antibody Cholesterol side chain cleavage enzyme Antibody Cholesterol side chain cleavage enzyme mitochondrial Antibody Cholesterol side-chain cleavage enzyme Antibody CP11A_HUMAN Antibody CYP11A Antibody CYP11A1 Antibody CYPXIA1 Antibody Cytochrome P450 11A1 Antibody Cytochrome P450 11A1 mitochondrial Antibody Cytochrome P450 family 11 subfamily A polypeptide 1 Antibody Cytochrome P450 subfamily XIA Antibody Cytochrome P450(scc) Antibody Cytochrome P450C11A1 Antibody mitochondrial Antibody P450SCC Antibody Steroid 20 22 lyase Antibody
Information:	Target information shown above is from the UniProt Consortium.