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Anti-CYP11A1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CYP11A1 Antibody

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Overview

Name:	Anti-CYP11A1 Antibody See all CYP11A1 primary antibodies
Description:	Rabbit polyclonal antibody to CYP11A1.
Applications:	WB, IF
Dilutions:	WB: 1:500 - 1:2000, IF: 1:20 - 1:50.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CYP11A1.
Protein Length:	521
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Involvement in Disease:	Adrenal insufficiency, congenital, with 46,XY sex reversal: A rare disorder that can present as acute adrenal insufficiency in infancy or childhood. ACTH and plasma renin activity are elevated and adrenal steroids are inappropriately low or absent; the 46,XY patients have female external genitalia, sometimes with clitoromegaly. The phenotypic spectrum ranges from prematurity, complete underandrogenization, and severe early-onset adrenal failure to term birth with clitoromegaly and later-onset adrenal failure. Patients with congenital adrenal insufficiency do not manifest the massive adrenal enlargement typical of congenital lipoid adrenal hyperplasia.
Sequence Similarities:	Belongs to the cytochrome P450 family.
Cellular Location:	Mitochondrion membrane.
Database Links:	Entrez Gene: 1583 Human Entrez Gene: 13070 Mouse Entrez Gene: 29680 Rat Omim: 118485 Human SwissProt: P05108 Human SwissProt: Q9QZ82 Mouse SwissProt: P14137 Rat Unigene: 303980 Human Unigene: 302865 Mouse Unigene: 1401 Rat
Synonyms:	Cholesterol 20 22 desmolase Antibody Cholesterol desmolase Antibody Cholesterol monooxygenase (side chain cleaving) Antibody Cholesterol side chain cleavage enzyme Antibody Cholesterol side chain cleavage enzyme mitochondrial Antibody Cholesterol side-chain cleavage enzyme Antibody CP11A_HUMAN Antibody CYP11A Antibody CYP11A1 Antibody CYPXIA1 Antibody Cytochrome P450 11A1 Antibody Cytochrome P450 11A1 mitochondrial Antibody Cytochrome P450 family 11 subfamily A polypeptide 1 Antibody Cytochrome P450 subfamily XIA Antibody Cytochrome P450(scc) Antibody Cytochrome P450C11A1 Antibody mitochondrial Antibody P450SCC Antibody Steroid 20 22 lyase Antibody
Information:	Target information shown above is from the UniProt Consortium.