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Anti-CXCR3 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CXCR3 Antibody

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Overview

Name:	Anti-CXCR3 Antibody See all CXCR3 primary antibodies
Description:	Rabbit polyclonal antibody to CXCR3
Specificity:	The antibody detects endogenous levels of total CXCR3 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human chemokine (C-X-C motif) receptor 3
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
Tissue Specificity:	Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Sequence Similarities:	Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification:	Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 2833?Human Omim: 300574?Human SwissProt: P49682?Human Unigene: 198252?Human
Synonyms:	C-X-C chemokine receptor type 3 Antibody CD 183 Antibody CD182 Antibody CD183 Antibody Chemokine (C X C motif) receptor 3 Antibody Chemokine (C X C) receptor 3 Antibody Chemokine CXC Motif Receptor 3 Antibody CKR L2 Antibody CKR-L2 Antibody CKRL2 Antibody CMKAR3 Antibody CXC-R3 Antibody CXCR-3 Antibody CXCR3 Antibody CXCR3_HUMAN Antibody G Protein Coupled Receptor 9 Antibody G protein-coupled receptor 9 Antibody GPR9 Antibody Interferon-inducible protein 10 receptor Antibody IP-10 receptor Antibody IP10 Antibody IP10 R Antibody IP10 receptor Antibody IP10-R Antibody IP10R Antibody Mig R Antibody Mig receptor Antibody Mig-R Antibody MIGR Antibody
Information:	Target information shown above is from the UniProt Consortium.