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Anti-CTSC Antibody

品牌：Antibodies

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规格：100µl

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Anti-CTSC Antibody

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Overview

Name:	Anti-CTSC Antibody See all CTSC primary antibodies
Description:	Rabbit polyclonal antibody to CTSC
Specificity:	The antibody detects endogenous levels of total CTSC protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human cathepsin C
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	3.1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
Tissue Specificity:	Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.
Involvement in Disease:	Papillon-Lefevre syndrome: An autosomal recessive disorder characterized by palmoplantar keratosis and severe periodontitis affecting deciduous and permanent dentitions and resulting in premature tooth loss. The palmoplantar keratotic phenotype vary from mild psoriasiform scaly skin to overt hyperkeratosis. Keratosis also affects other sites such as elbows and knees. Haim-Munk syndrome: An autosomal recessive disorder characterized by palmoplantar keratosis, onychogryphosis and periodontitis. Additional features are pes planus, arachnodactyly, and acroosteolysis. Periodontititis, aggressive, 1: A disease characterized by severe and protracted gingival infections, generalized or localized, leading to tooth loss. Amounts of microbial deposits are generally inconsistent with the severity of periodontal tissue destruction and the progression of attachment and bone loss may be self arresting.
Sequence Similarities:	Belongs to the peptidase C1 family.
Post-Translational Modification:	N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.
Cellular Location:	Lysosome.
Database Links:	Entrez Gene: 1075?Human Omim: 602365?Human SwissProt: P53634?Human Unigene: 128065?Human
Synonyms:	AI047818 Antibody CATC Antibody CATC_HUMAN Antibody Cathepsin C Antibody Cathepsin J Antibody CPPI Antibody CTSC Antibody Dipeptidyl peptidase 1 Antibody Dipeptidyl peptidase 1 light chain Antibody Dipeptidyl peptidase I Antibody Dipeptidyl peptidase I exclusion domain chain Antibody Dipeptidyl peptidase I heavy chain Antibody Dipeptidyl peptidase I light chain Antibody Dipeptidyl transferase Antibody DPP I Antibody DPP-I Antibody DPP1 Antibody DPPI Antibody EC 3.4.14.1 Antibody HMS Antibody JP Antibody JPD Antibody MGC126959 Antibody PALS Antibody PDON1 Antibody PLS Antibody
Information:	Target information shown above is from the UniProt Consortium.