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Anti-CSRP3 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CSRP3 Antibody

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Overview

Name:	Anti-CSRP3 Antibody See all CSRP3 primary antibodies
Description:	Rabbit polyclonal antibody to CSRP3
Specificity:	The antibody detects endogenous level of total CSRP3 antibody.
Applications:	WB, IF
Reactivity:	Human, Mouse
Immunogen:	Recombinant protein of human CSRP3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C

Target

Function:	Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity).
Tissue Specificity:	Cardiac and slow-twitch skeletal muscles. Isoform 2 is expressed in striated muscle. Isoform 2 is specifically expressed at higher levels in patients with neuromuscular diseases, such as limb-girdle muscular dystrophy 2A (LGMD2A), Duchenne muscular dystrophy (DMD) and dermatomyositis (PubMed:24860983).
Involvement in Disease:	Cardiomyopathy, dilated 1M: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Cardiomyopathy, familial hypertrophic 12: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Post-Translational Modification:	Phosphorylated by PKC/PRKCA.
Cellular Location:	Nucleus. Cytoplasm. Cytoplasm > Cytoskeleton. Cytoplasm > Myofibril > Sarcomere > Z line. Cytoplasm > Myofibril > Sarcomere. Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity).
Database Links:	Entrez Gene: 8048 Human Entrez Gene: 13009 Mouse Omim: 600824 Human SwissProt: P50461 Human SwissProt: P50462 Mouse Unigene: 83577 Human Unigene: 17235 Mouse
Synonyms:	cardiac Antibody Cardiac LIM protein Antibody CLP Antibody CMD1M Antibody CMH12 Antibody CRP3 Antibody CSRP3 Antibody CSRP3_HUMAN Antibody Cysteine and glycine-rich protein 3 Antibody Cysteine rich protein 3 Antibody Cysteine-rich protein 3 Antibody LIM domain only 4 Antibody LIM domain protein Antibody LMO4 Antibody MLP Antibody Muscle LIM protein Antibody
Information:	Target information shown above is from the UniProt Consortium.