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Anti-CSNK1G2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CSNK1G2 Antibody

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Overview

Name:	Anti-CSNK1G2 Antibody See all CSNK1G2 primary antibodies
Description:	Rabbit polyclonal antibody to CSNK1G2.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human
Immunogen:	Recombinant protein of human CSNK1G2.
Protein Length:	415
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Tissue Specificity:	Testis.
Sequence Similarities:	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Post-Translational Modification:	Autophosphorylated.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 1455?Human Omim: 602214?Human SwissProt: P78368?Human Unigene: 651905?Human
Synonyms:	Casein Kinase 1 gamma 2 Antibody Casein kinase 1, gamma 2 Antibody Casein kinase I isoform gamma 2 Antibody Casein kinase I isoform gamma-2 Antibody CK1g2 Antibody CKI gamma 2 Antibody CKI-gamma 2 Antibody CSNK1G 2 Antibody Csnk1g2 Antibody KC1G2_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.