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Anti-CREM (I106) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CREM (I106) Antibody

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Name:	Anti-CREM (I106) Antibody See all CREM primary antibodies
Description:	Rabbit polyclonal antibody to CREM (I106)
Specificity:	CREM (I106) pAb detects endogenous levels of CREM protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 80-130 of Human CREM.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 35 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
Tissue Specificity:	Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Sequence Similarities:	Belongs to the bZIP family.
Post-Translational Modification:	Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 1390?Human Entrez Gene: 12916?Mouse Entrez Gene: 25620?Rat Omim: 123812?Human SwissProt: Q03060?Human SwissProt: P27699?Mouse SwissProt: Q03061?Rat Unigene: 200250?Human Unigene: 5244?Mouse Unigene: 10251?Rat
Synonyms:	cAMP response element modulator Antibody cAMP responsive element modulator Antibody cAMP-responsive element modulator Antibody CREM Antibody CREM-2 Antibody CREM_HUMAN Antibody hCREM 2 Antibody hCREM-2 Antibody hCREM2 Antibody ICER Antibody Inducible cAMP early repressor Antibody Inducible cAMP early repressor ICER Antibody MGC111110 Antibody MGC17881 Antibody MGC41893 Antibody
Information:	Target information shown above is from the UniProt Consortium.