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Anti-CREB3L2 Antibody

品牌：Antibodies

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规格：100µg

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Anti-CREB3L2 Antibody

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Overview

Name:	Anti-CREB3L2 Antibody See all CREB3L2 primary antibodies
Description:	Goat polyclonal antibody to CREB3L2.
Applications:	ELISA, WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human CREB3L2 (N terminal).
Sequence:	DRKLSELSEPGDGE-C
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).
Tissue Specificity:	Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.
Sequence Similarities:	Belongs to the bZIP family. ATF subfamily.
Post-Translational Modification:	Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2).
Cellular Location:	Endoplasmic reticulum membrane. ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus.
Database Links:	Entrez Gene: 64764?Human Omim: 608834?Human SwissProt: Q70SY1?Human Unigene: 490273?Human
Synonyms:	B ZIB transcription factor Antibody Basic transcription factor 2 Antibody BBF2 human homolog on chromosome 7 Antibody BBF2H7 Antibody BZIB transcription factor Antibody cAMP responsive element binding protein 3 like 2 Antibody cAMP-responsive element-binding protein 3-like protein 2 Antibody CR3L2_HUMAN Antibody CREB3L2 Antibody Cyclic AMP-responsive element-binding protein 3-like protein 2 Antibody FUS/BBF2H7 protein Antibody MGC131709 Antibody MGC71006 Antibody Processed cyclic AMP-responsive element-binding protein 3-like protein 2 Antibody TCAG_1951439 Antibody
Information:	Target information shown above is from the UniProt Consortium.