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Anti-COPS6 Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-COPS6 Antibody

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Overview

Name:	Anti-COPS6 Antibody See all COPS6 primary antibodies
Description:	Rabbit polyclonal antibody to COPS6.
Applications:	WB, IF
Dilutions:	WB: 1:500 - 1:2000, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human COPS6.
Protein Length:	327
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets.
Tissue Specificity:	Widely expressed.
Sequence Similarities:	Belongs to the peptidase M67A family. CSN6 subfamily.
Cellular Location:	Nucleus. Cytoplasm. The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.
Database Links:	Entrez Gene: 10980 Human Entrez Gene: 26893 Mouse Omim: 614729 Human SwissProt: Q7L5N1 Human SwissProt: O88545 Mouse Unigene: 15591 Human Unigene: 3981 Mouse
Synonyms:	COP9 (constitutive photomorphogenic), subunit 6; COP9 complex S6 Antibody COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) Antibody COP9 signalosome complex subunit 6 Antibody COP9 signalosome subunit 6 Antibody COP9 subunit 6 (MOV34 homolog, 34 kD) Antibody COPS6 Antibody CSN6 Antibody CSN6_HUMAN Antibody hVIP Antibody H_NH0506M12.12 Antibody JAB1 containing signalosome subunit 6 Antibody JAB1-containing signalosome subunit 6 Antibody MOV34 homolog Antibody MOV34 homolog, 34 kD Antibody MOV34-34KD Antibody OTTMUSP00000025868 Antibody Sgn3 Antibody SGN6 Antibody Signalosome subunit 6 Antibody VIP/MOV34 Antibody Vpr interacting protein Antibody Vpr-interacting protein Antibody
Information:	Target information shown above is from the UniProt Consortium.