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Anti-COPS2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-COPS2 Antibody

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Overview

Name:	Anti-COPS2 Antibody See all COPS2 primary antibodies
Description:	Rabbit polyclonal antibody to COPS2
Specificity:	The antibody detects endogenous levels of total COPS2 protein.
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from internal of human COPS2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C

Target

Function:	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Sequence Similarities:	Belongs to the CSN2 family.
Post-Translational Modification:	Phosphorylated by CK2 and PKD kinases.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 9318 Human Entrez Gene: 12848 Mouse Entrez Gene: 261736 Rat Omim: 604508 Human SwissProt: P61201 Human SwissProt: P61202 Mouse SwissProt: P61203 Rat Unigene: 369614 Human Unigene: 3596 Mouse Unigene: 11556 Rat
Synonyms:	ALIEN Antibody Alien Drosophila himolog of Antibody Alien homolog Antibody COP 9 Antibody COP9 Antibody COP9 constitutive photomorphogenic homolog subunit 2 Antibody COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) Antibody COP9 signalosome complex subunit 2 Antibody COPS 2 Antibody Cops2 Antibody CSN2 Antibody CSN2_HUMAN Antibody JAB1 containing signalosome subunit 2 Antibody JAB1-containing signalosome subunit 2 Antibody SGN 2 Antibody SGN2 Antibody Signalosome subunit 2 Antibody Thyroid Hormone Receptor Interactor 15 Antibody Thyroid Hormone Receptor Interactor15 Antibody Thyroid receptor-interacting protein 15 Antibody TR-interacting protein 15 Antibody TRIP 15 Antibody TRIP-15 Antibody TRIP15 Antibody
Information:	Target information shown above is from the UniProt Consortium.