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Anti-Copine-3 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Copine-3 Antibody

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Overview

Name:	Anti-Copine-3 Antibody See all Copine-3 primary antibodies
Description:	Rabbit polyclonal antibody to Copine-3
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 234 and 533 of Human CPNE3
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).
Tissue Specificity:	Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870).
Sequence Similarities:	Belongs to the copine family.
Post-Translational Modification:	Phosphorylated on serine and threonine residues (PubMed:11041869).
Cellular Location:	Nucleus. Cytoplasm. Cell membrane. Cell junction. Cell junction > Focal adhesion. Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870).
Database Links:	Entrez Gene: 8895?Human Omim: 604207?Human SwissProt: O75131?Human Unigene: 191219?Human
Synonyms:	Copine 3 Antibody Copine III Antibody Copine-3 Antibody Copine3 Antibody CopineIII Antibody CPN3 Antibody CPNE 3 Antibody CPNE3 Antibody CPNE3_HUMAN Antibody KIAA0636 Antibody PRO1071 Antibody
Information:	Target information shown above is from the UniProt Consortium.