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Anti-CMKLR1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CMKLR1 Antibody

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Overview

Name:	Anti-CMKLR1 Antibody See all CMKLR1 primary antibodies
Description:	Rabbit polyclonal antibody to CMKLR1
Specificity:	The antibody detects endogenous levels of total CMKLR1 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide of human CMKLR1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.3mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Tissue Specificity:	Prominently expressed in developing osseous and cartilaginous tissue. Also found in ***** parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.
Sequence Similarities:	Belongs to the G-protein coupled receptor 1 family.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 1240?Human Omim: 602351?Human SwissProt: Q99788?Human Unigene: 197143?Human
Synonyms:	CHEMERINR Antibody Chemokine like receptor 1 Antibody Chemokine-like receptor 1 Antibody CHEMR23 Antibody CMKLR1 Antibody CML1_HUMAN Antibody DEZ Antibody G protein coupled receptor ChemR23 Antibody G protein coupled receptor DEZ Antibody G-protein coupled receptor ChemR23 Antibody G-protein coupled receptor DEZ Antibody Orphan G protein coupled receptor Antibody Orphan G protein coupled receptor Dez Antibody Resolvin E1 receptor Antibody RVER1 Antibody
Information:	Target information shown above is from the UniProt Consortium.