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Anti-Clusterin Antibody

品牌：Antibodies

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规格：100µl

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Anti-Clusterin Antibody

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Overview

Name:	Anti-Clusterin Antibody See all Clusterin primary antibodies
Description:	Rabbit polyclonal antibody to Clusterin
Specificity:	The antibody detects endogenous level of total Clusterin polyclonal antibody.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Recombinant human Clusterin protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Caprylic Acid Ammonium Sulfate Precipitation purified
Concentration:	1.0mg / mL
Formulation:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage:	Store at -20?C

Target

Function:	Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
Tissue Specificity:	Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.
Sequence Similarities:	Belongs to the clusterin family.
Post-Translational Modification:	Isoform 1 is proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen.
Cellular Location:	Secreted. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.
Database Links:	Entrez Gene: 1191?Human Omim: 185430?Human SwissProt: P10909?Human Unigene: 436657?Human
Synonyms:	40 Antibody AAG 4 Antibody AAG4 Antibody Aging associated protein 4 Antibody Aging-associated gene 4 protein Antibody AI893575 Antibody APO J Antibody Apo-J Antibody APOJ Antibody ApoJalpha Antibody ApoJbeta Antibody Apolipoprotein J Antibody ApolipoproteinJ Antibody CLI Antibody CLU Antibody CLU1 Antibody CLU2 Antibody Clusterin Antibody Clusterin alpha chain Antibody Clusterin beta chain Antibody CLUS_HUMAN Antibody Complement associated protein SP 40 Antibody Complement associated protein SP 40 40 Antibody Complement associated protein SP40 Antibody Complement cytolysis inhibitor Antibody Complement cytolysis inhibitor a chain Antibody Complement cytolysis inhibitor b chain Antibody Complement lysis inhibitor Antibody Complement-associated protein SP-40 Antibody D14Ucla3 Antibody Dimeric acid glycoprotein Antibody Glycoprotein 80 Antibody Glycoprotein III Antibody GP80 Antibody Ku70-binding protein 1 Antibody KUB 1 Antibody KUB1 Antibody MGC24903 Antibody NA1/NA2 Antibody RATTRPM2B Antibody SGP 2 Antibody SGP2 Antibody SP 40 Antibody SP40 Antibody Sugp-2 Antibody Sulfated glycoprotein 2 Antibody Testosterone repressed prostate message 2 Antibody Testosterone-repressed prostate message 2 Antibody TRPM 2 Antibody TRPM-2 Antibody TRPM2 Antibody TRPM2B Antibody Trpmb Antibody
Information:	Target information shown above is from the UniProt Consortium.