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Anti-CLDN1 Antibody

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规格：50µl

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Anti-CLDN1 Antibody

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Overview

Name:	Anti-CLDN1 Antibody See all CLDN1 primary antibodies
Description:	Rabbit polyclonal antibody to CLDN1
Specificity:	The antibody detects endogenous level of total CLDN1 protein.
Applications:	E, WB, IHC
Dilutions:	ELISA: 1:1000-1:10000 Western blotting: 1:2000-1:5000 Immunohistochemistry: 1:100-1:300
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from 196-209 amino acids of Human claudin 1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Predicted MW:	23kd
Formulation:	Supplied at 3.8mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Function:	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
Tissue Specificity:	Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
Involvement in Disease:	Ichthyosis-sclerosing cholangitis neonatal syndrome: A rare autosomal recessive complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia, mild diffuse ichthyosis, sclerosing cholangitis and leukocyte vacuolization.
Sequence Similarities:	Belongs to the claudin family.
Cellular Location:	Cell junction > Tight junction. Cell membrane.
Database Links:	Entrez Gene: 9076?Human Omim: 603718?Human SwissProt: O95832?Human Unigene: 439060?Human
Synonyms:	Claudin 1 Antibody Claudin-1 Antibody Claudin1 Antibody CLD 1 Antibody CLD1 Antibody CLD1_HUMAN Antibody CLDN 1 Antibody Cldn1 Antibody ILVASC Antibody SEMP 1 Antibody SEMP1 Antibody Senescence associated epithelial membrane protein Antibody Senescence associated epithelial membrane protein 1 Antibody Senescence-associated epithelial membrane protein Antibody
Information:	Target information shown above is from the UniProt Consortium.