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Anti-Claudin-7 (S204) Antibody

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规格：50µl

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Anti-Claudin-7 (S204) Antibody

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Overview

Name:	Anti-Claudin-7 (S204) Antibody See all Claudin-7 primary antibodies
Description:	Rabbit polyclonal antibody to Claudin-7 (S204)
Specificity:	Claudin-7 (S204) pAb detects endogenous levels of Claudin-7 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-7.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 23,32kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Plays a major role in tight junction-specific obliteration of the intercellular space.
Tissue Specificity:	Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Sequence Similarities:	Belongs to the claudin family.
Post-Translational Modification:	Phosphorylated.
Cellular Location:	Cell membrane. Lateral cell membrane. Cell junction > Tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction.
Database Links:	Entrez Gene: 1366?Human Entrez Gene: 53624?Mouse Entrez Gene: 65132?Rat Omim: 609131?Human SwissProt: O95471?Human SwissProt: Q9Z261?Mouse SwissProt: Q9Z1L1?Rat Unigene: 513915?Human Unigene: 281896?Mouse Unigene: 32259?Rat
Synonyms:	CEPTR L2 Antibody CEPTRL 2 Antibody CEPTRL2 Antibody Claudin 1 Antibody Claudin 7 Antibody Claudin 9 Antibody Claudin-7 Antibody Claudin1 Antibody Claudin7 Antibody Claudin9 Antibody CLD7_HUMAN Antibody CLDN 7 Antibody CLDN-7 Antibody CLDN7 Antibody Clostridium perfringens enterotoxin receptor like 2 Antibody CPETR L2 Antibody CPETRL 2 Antibody CPETRL2 Antibody Hs.84359 Antibody
Information:	Target information shown above is from the UniProt Consortium.