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Anti-Clathrin Heavy Chain Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-Clathrin Heavy Chain Antibody

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Overview

Name:	Anti-Clathrin Heavy Chain Antibody See all Clathrin Heavy Chain primary antibodies
Description:	Mouse monoclonal (BF-06) antibody to Clathrin Heavy Chain.
Specificity:	The antibody BF-06 recognizes clathrin heavy chain, an ubiquitously expressed 180 kDa protein involved in receptor-mediated endocytosis.
Applications:	FC, IP, WB, ICC, ELISA
Reactivity:	Human, Porcine, Mouse, Rat, Bovine
Host:	Mouse
Clonality:	Monoclonal
Clone:	BF-06
Isotype:	IgM
Conjugate:	Unconjugated
Purification:	Purified from ascites by precipitation methods and ion exchange chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 8.0, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577,PubMed:16968737). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). Plays a role in early autophagosome formation (By similarity).
Sequence Similarities:	Belongs to the clathrin heavy chain family.
Cellular Location:	Cytoplasmic vesicle membrane. Membrane > Coated pit. Melanosome. Cytoplasm > Cytoskeleton > Spindle. Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
Database Links:	Entrez Gene: 281080 Cow Entrez Gene: 1213 Human Entrez Gene: 67300 Mouse Entrez Gene: 54241 Rat Omim: 118955 Human SwissProt: P49951 Cow SwissProt: P53675 Human SwissProt: Q00610 Human SwissProt: Q68FD5 Mouse SwissProt: P11442 Rat Unigene: 491351 Human Unigene: 479526 Mouse Unigene: 3589 Rat
Synonyms:	CHC17 Antibody Clathrin heavy chain Antibody Clathrin heavy chain 1 Antibody Clathrin heavy chain 2 Antibody Clathrin heavy chain like 1 Antibody Clathrin heavy chain on chromosome 17 Antibody Clathrin heavy polypeptide Antibody CLH 17 Antibody CLH 22 Antibody CLH-17 Antibody CLH17 Antibody CLH1_HUMAN Antibody CLH22 Antibody CLTC Antibody CLTCL Antibody CLTCL1 Antibody CLTCL2 Antibody CLTD Antibody Hc Antibody KIAA0034 Antibody
Information:	Target information shown above is from the UniProt Consortium.