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Anti-CIP75 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CIP75 Antibody

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Overview

Name:	Anti-CIP75 Antibody See all CIP75 primary antibodies
Description:	Rabbit polyclonal antibody to CIP75
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against an 18 amino acid peptide near the amino terminus of human CIP75.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (By similarity). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (PubMed:18079109, PubMed:20940304). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (By similarity).
Tissue Specificity:	Detected in testis, ovary, thyroid, kidney, thymus, heart, liver, lung and spleen (at protein level). Highly expressed in heart, skeletal muscle, kidney, liver and brain. Detected at lower levels in testis, lung and spleen.
Post-Translational Modification:	Ubiquitinated; this does not lead to proteasomal degradation. May undergo both 'Lys-48'- and 'Lys-63'-linked polyubiquitination (By similarity).
Cellular Location:	Nucleus. Cytoplasm. Endoplasmic reticulum. Cytoplasm > Perinuclear region. Cytoplasmic vesicle > Autophagosome. Colocalizes with the proteasome, both in nucleus and cytoplasm (By similarity).
Database Links:	Entrez Gene: 56893?Human Entrez Gene: 94232?Mouse Entrez Gene: 310633?Rat Omim: 605440?Human SwissProt: Q9NRR5?Human SwissProt: Q99NB8?Mouse Unigene: 283739?Human Unigene: 303059?Mouse
Synonyms:	28S ribosomal protein S7 Antibody A1U Antibody A1Up Antibody AI663987 Antibody Ataxin 1 interacting ubiquitin like protein Antibody Ataxin 1 ubiquitin like interacting protein Antibody Ataxin 1 ubiquitin like interacting protein A1U Antibody Ataxin-1 ubiquitin-like-interacting protein A1U Antibody bMRP 27a Antibody bMRP27a Antibody C1orf6 Antibody CIP75 Antibody Connexin43 interacting protein of 75 kDa Antibody MRP S7 Antibody RGD1308273 Antibody S7mt Antibody UBIN Antibody Ubiquilin 4 Antibody Ubiquilin-4 Antibody UBQL4_HUMAN Antibody UBQLN4 Antibody
Information:	Target information shown above is from the UniProt Consortium.