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Anti-CHUK Antibody

品牌：Antibodies

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规格：100µg

货期：

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Anti-CHUK Antibody

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Overview

Name:	Anti-CHUK Antibody See all IKK alpha primary antibodies
Description:	Goat polyclonal antibody to CHUK.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human CHUK (internal region).
Sequence:	EHDHSLSCVVTPQD
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3. Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260).
Tissue Specificity:	Widely expressed.
Involvement in Disease:	Cocoon syndrome: A lethal syndrome characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Post-Translational Modification:	Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
Cellular Location:	Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus.
Database Links:	Entrez Gene: 1147 Human Omim: 600664 Human SwissProt: O15111 Human Unigene: 198998 Human
Synonyms:	chuk Antibody CHUK1 Antibody Conserved Helix Loop Helix Ubiquitous Kinase Antibody Conserved helix loop ubiquitous kinase Antibody Conserved helix-loop-helix ubiquitous kinase Antibody I Kappa B Kinase 1 Antibody I Kappa B Kinase Alpha Antibody I-kappa-B kinase 1 Antibody I-kappa-B kinase alpha Antibody IkappaB kinase Antibody IkB kinase alpha subunit Antibody IkBKA Antibody IKK 1 Antibody IKK A Antibody IKK a kinase Antibody IKK alpha Antibody IKK-A Antibody IKK-alpha Antibody IKK1 Antibody IKKA Antibody IKKA_HUMAN Antibody Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells Antibody Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit Antibody Inhibitor of nuclear factor kappa-B kinase subunit alpha Antibody NFKBIKA Antibody Nuclear Factor Kappa B Inhibitor Kinase Alpha Antibody Nuclear factor NF kappa B inhibitor kinase alpha Antibody Nuclear factor NF-kappa-B inhibitor kinase alpha Antibody Nuclear factor NFkappaB inhibitor kinase alpha Antibody Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor Antibody TCF-16 Antibody TCF16 Antibody Transcription factor 16 Antibody
Information:	Target information shown above is from the UniProt Consortium.