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Anti-cGKII Antibody

品牌：Antibodies

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规格：50µl

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Anti-cGKII Antibody

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Overview

Name:	Anti-cGKII Antibody See all cGKII primary antibodies
Description:	Rabbit polyclonal antibody to cGKII
Specificity:	cGKII Polyclonal Antibody detects endogenous levels of cGKII protein.
Applications:	WB, IHC, ELISA
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from human cGKII around the non-phosphorylation site of S126.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
Tissue Specificity:	Highly concentrated in brain, lung and intestinal mucosa.
Sequence Similarities:	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
Post-Translational Modification:	Myristoylation mediates membrane localization.
Cellular Location:	Apical cell membrane.
Database Links:	Entrez Gene: 5593?Human Entrez Gene: 19092?Mouse Entrez Gene: 25523?Rat Omim: 601591?Human SwissProt: Q13237?Human SwissProt: Q61410?Mouse SwissProt: Q64595?Rat Unigene: 570833?Human Unigene: 263002?Mouse Unigene: 87721?Rat
Synonyms:	CGK 2 Antibody CGK2 Antibody cGKII Antibody cGMP dependent protein kinase 2 Antibody cGMP-dependent protein kinase 2 Antibody cGMP-dependent protein kinase II Antibody KGP2_HUMAN Antibody PRKG 2 Antibody PRKG2 Antibody PRKGR2 Antibody Protein kinase, cGMP dependent, type II Antibody Type II cGMP dependent protein kinase Antibody
Information:	Target information shown above is from the UniProt Consortium.