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Anti-CFI Antibody

品牌：Antibodies

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规格：50µl

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Anti-CFI Antibody

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Overview

Name:	Anti-CFI Antibody See all CFI primary antibodies
Description:	Rabbit polyclonal antibody to CFI.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human
Immunogen:	Recombinant protein of human CFI.
Protein Length:	583
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
Tissue Specificity:	Plasma.
Involvement in Disease:	Hemolytic uremic syndrome atypical 3: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Complement factor I deficiency: Autosomal recessive condition associated with a propensity to pyogenic infections. Macular degeneration, age-related, 13: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Sequence Similarities:	Belongs to the peptidase S1 family.
Cellular Location:	Secreted > Extracellular space.
Database Links:	Entrez Gene: 3426?Human Omim: 217030?Human SwissProt: P05156?Human Unigene: 312485?Human
Synonyms:	AHUS3 Antibody ARMD13 Antibody C3b INA Antibody C3b inactivator Antibody C3B/C4B inactivator Antibody C3BINA Antibody CFAI_HUMAN Antibody Cfi Antibody Complement component I Antibody Complement control protein factor I Antibody Complement factor I Antibody Complement factor I heavy chain Antibody Complement factor I light chain Antibody F1 Antibody Factor I Antibody FactorI Antibody FI Antibody I factor Antibody IF Antibody KAF Antibody Konglutinogen activating factor Antibody Light chain of factor I Antibody OTTHUMP00000219728 Antibody OTTHUMP00000221928 Antibody
Information:	Target information shown above is from the UniProt Consortium.