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Anti-CFB Antibody

品牌：Antibodies

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规格：100µl

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Anti-CFB Antibody

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Overview

Name:	Anti-CFB Antibody See all CFB primary antibodies
Description:	Rabbit polyclonal antibody to CFB
Specificity:	The antibody detects endogenous level of total CFB protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CFB.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
Involvement in Disease:	Hemolytic uremic syndrome atypical 4: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Complement factor B deficiency: An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
Sequence Similarities:	Belongs to the peptidase S1 family.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 629?Human Entrez Gene: 14962?Mouse Entrez Gene: 294257?Rat Omim: 138470?Human SwissProt: P00751?Human SwissProt: P04186?Mouse Unigene: 69771?Human Unigene: 653?Mouse Unigene: 109148?Rat
Synonyms:	AHUS4 Antibody B factor properdin Antibody BF Antibody BFD Antibody C3 proaccelerator Antibody C3 proactivator Antibody C3/C5 convertase Antibody CFAB Antibody CFAB_HUMAN Antibody CFB Antibody Complement Factor B Antibody Complement factor B Bb fragment Antibody Factor B Antibody FB Antibody FBI12 Antibody GBG Antibody Glycine rich beta glycoprotein Antibody Glycine-rich beta glycoprotein Antibody H2 Bf Antibody H2BF Antibody PBF2 Antibody Properdin factor B Antibody
Information:	Target information shown above is from the UniProt Consortium.