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Anti-Cerebral 1 (L310) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Cerebral 1 (L310) Antibody

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Name:	Anti-Cerebral 1 (L310) Antibody See all Cerebral 1 primary antibodies
Description:	Rabbit polyclonal antibody to Cerebral 1 (L310)
Specificity:	Cerebral 1 (L310) pAb detects endogenous levels of Cerebral 1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 291-340 of Human Cerebral 1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 51 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Sequence Similarities:	Belongs to the methyltransferase superfamily. RRP8 family.
Cellular Location:	Nucleus > Nucleolus. Localizes at rDNA locus.