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Anti-CENPA Antibody

品牌：Antibodies

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规格：100µl

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Anti-CENPA Antibody

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Overview

Name:	Anti-CENPA Antibody See all CENPA primary antibodies
Description:	Rabbit polyclonal antibody to CENPA
Applications:	ELISA, IHC, WB
Reactivity:	Human
Immunogen:	Rabbit polyclonal CENPA antibody was raised against a peptide from a peptide from the C terminal residues of human CENPA protein.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity purified
Concentration:	1.0mg / ml
Formulation:	PBS, pH 7.4 with 0.02% Sodium Azide
Storage:	This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Target

Function:	Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292).
Sequence Similarities:	Belongs to the histone H3 family.
Post-Translational Modification:	Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.
Cellular Location:	Nucleus. Chromosome > Centromere > Kinetochore. Chromosome > Centromere. Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591). Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658).
Database Links:	Entrez Gene: 1058?Human Omim: 117139?Human SwissProt: P49450?Human Unigene: 1594?Human
Synonyms:	CENP A Antibody CENP-A Antibody CENPA Antibody CENPA_HUMAN Antibody Centromere autoantigen A Antibody Centromere protein A Antibody Centromere protein A 17kDa Antibody Histone H3 like centromeric protein A Antibody Histone H3-like centromeric protein A Antibody
Information:	Target information shown above is from the UniProt Consortium.