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Anti-CDK8 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CDK8 Antibody

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Overview

Name:	Anti-CDK8 Antibody See all CDK8 primary antibodies
Description:	Rabbit polyclonal antibody to CDK8
Specificity:	The antibody detects endogenous level of total CDK8 polyclonal antibody.
Applications:	IHC
Reactivity:	Human
Immunogen:	Recombinant human Cyclin-dependent kinase 8 protein(365-464aa)
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen Affinity purified
Concentration:	1.0mg / mL
Formulation:	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:	Store at -20?C

Target

Function:	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Sequence Similarities:	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 1024?Human Omim: 603184?Human SwissProt: P49336?Human Unigene: 382306?Human
Synonyms:	Cdk8 Antibody CDK8 protein kinase Antibody CDK8_HUMAN Antibody Cell Division Kinase 8 Antibody Cell division protein kinase 8 Antibody Cyclin Dependent kinase 8 Antibody Cyclin-dependent kinase 8 Antibody K35 Antibody Mediator complex subunit cdk8 Antibody Mediator of RNA polymerase II transcription subunit cdk8 Antibody Protein kinase K35 Antibody
Information:	Target information shown above is from the UniProt Consortium.