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Anti-CDK7 (L325) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CDK7 (L325) Antibody

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Overview

Name:	Anti-CDK7 (L325) Antibody See all CDK7 primary antibodies
Description:	Rabbit polyclonal antibody to CDK7 (L325)
Specificity:	CDK7 (L325) pAb detects endogenous levels of CDK7 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 300-350 of Human CDK7.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 39 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Post-Translational Modification:	Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2.
Cellular Location:	Nucleus. Cytoplasm. Cytoplasm > Perinuclear region. Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.
Database Links:	Entrez Gene: 1022?Human Entrez Gene: 12572?Mouse Entrez Gene: 171150?Rat Omim: 601955?Human SwissProt: P50613?Human SwissProt: Q03147?Mouse SwissProt: P51952?Rat Unigene: 184298?Human Unigene: 259718?Mouse Unigene: 98896?Rat
Synonyms:	39 kDa protein kinase Antibody CAK Antibody CAK1 Antibody Cdk activating kinase Antibody CDK-activating kinase Antibody CDK-activating kinase 1 Antibody Cdk7 Antibody CDK7_HUMAN Antibody CDKN7 Antibody Cell division protein kinase 7 Antibody Cyclin dependent kinase 7 Antibody Cyclin-dependent kinase 7 Antibody cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) Antibody HCAK Antibody Homolog of Xenopus MO15 Cdk activating kinase Antibody Kinase subunit of CAK Antibody MO15 Antibody MO15, Xenopus, homolog of Antibody P39 Mo15 Antibody p39MO15 Antibody Serine threonine kinase Stk1 Antibody Serine/threonine protein kinase 1 Antibody Serine/threonine protein kinase MO15 Antibody STK1 Antibody TFIIH basal transcription factor complex kinase subunit Antibody
Information:	Target information shown above is from the UniProt Consortium.