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Anti-CDK5R1 (Q31) Antibody

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规格：50µl

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Anti-CDK5R1 (Q31) Antibody

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Overview

Name:	Anti-CDK5R1 (Q31) Antibody See all CDK5R1 primary antibodies
Description:	Rabbit polyclonal antibody to CDK5R1 (Q31)
Specificity:	CDK5R1 (Q31) pAb detects endogenous levels of CDK5R1-p35 protein, and does not cross-react with CDK5R1-p25 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 1-54 of Human p35.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 35 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Tissue Specificity:	Brain and neuron specific.
Sequence Similarities:	Belongs to the cyclin-dependent kinase 5 activator family.
Post-Translational Modification:	The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity).
Cellular Location:	Cell membrane. In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
Database Links:	Entrez Gene: 8851?Human Entrez Gene: 12569?Mouse Entrez Gene: 116671?Rat Omim: 603460?Human SwissProt: Q15078?Human SwissProt: P61809?Mouse SwissProt: P61810?Rat Unigene: 500015?Human Unigene: 142275?Mouse Unigene: 474282?Mouse Unigene: 11213?Rat
Synonyms:	CD5R1_HUMAN Antibody CDK5 activator 1 Antibody CDK5P35 Antibody CDK5R Antibody CDK5R1 Antibody Cyclin dependent kinase 5 regulatory subunit 1 Antibody Cyclin-dependent kinase 5 activator 1 Antibody Cyclin-dependent kinase 5 regulatory subunit 1 Antibody NCK 5A Antibody Neuronal CDK5 activator Antibody p23 Antibody p25 Antibody p35 Antibody Regulatory partner for CDK5 kinase Antibody Tau protein kinase II 23 kDa subunit Antibody TPKII regulatory subunit Antibody
Information:	Target information shown above is from the UniProt Consortium.