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Anti-CDK12 Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-CDK12 Antibody

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Overview

Name:	Anti-CDK12 Antibody See all CDK12 primary antibodies
Description:	Rabbit polyclonal antibody to CDK12
Specificity:	The antibody detects endogenous levels of total CDK12 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human cyclin-dependent kinase 12
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	3.1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Tissue Specificity:	Ubiquitously expressed.
Sequence Similarities:	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Post-Translational Modification:	Phosphorylation at Thr-893 increases kinase activity.
Cellular Location:	Nucleus. Nucleus speckle. Colocalized with nuclear speckles throughout interphase.
Database Links:	Entrez Gene: 51755?Human Omim: 615514?Human SwissProt: Q9NYV4?Human Unigene: 416108?Human
Synonyms:	arginine/serine-rich Antibody Cdc2 related kinase arginine/serine rich Antibody CDC2 related protein kinase 7 Antibody Cdc2-related kinase Antibody CDC2-related protein kinase 7 Antibody Cdk12 Antibody CDK12_HUMAN Antibody Cell division cycle 2 related protein kinase 7 Antibody Cell division cycle 2-related protein kinase 7 Antibody Cell division protein kinase 12 Antibody CRK7 Antibody CRKR Antibody CrkRS Antibody Cyclin-dependent kinase 12 Antibody EC 2.7.11.22 Antibody hCDK12 Antibody kiaa0904 Antibody Pksc Antibody
Information:	Target information shown above is from the UniProt Consortium.