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Anti-CDCA1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CDCA1 Antibody

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Overview

Name:	Anti-CDCA1 Antibody See all CDCA1 primary antibodies
Description:	Rabbit polyclonal antibody to CDCA1
Applications:	WB, IF
Dilutions:	Western blotting: 1:500-1:3000 Immunofluorescence: 1:100-1:200
Reactivity:	Human
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.

Target

Function:	Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule s in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Sequence Similarities:	Belongs to the NUF2 family.
Post-Translational Modification:	Can be phosphorylated by AURKA and AURKB.
Cellular Location:	Nucleus. Chromosome > Centromere > Kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.
Database Links:	Entrez Gene: 83540 Human Omim: 611772 Human SwissProt: Q9BZD4 Human Unigene: 651950 Human
Synonyms:	Cancer/testis antigen 106 Antibody CDCA 1 Antibody CDCA1 Antibody Cell division cycle associated 1 Antibody Cell division cycle associated protein 1 Antibody Cell division cycle-associated protein 1 Antibody CT106 Antibody hNuf 2 Antibody hNuf2 Antibody hNuf2R Antibody hsNuf2 Antibody Kinetochore protein Nuf2 Antibody Nuf 2 Antibody Nuf2 Antibody NUF2 NDC80 kinetochore complex component Antibody NUF2 NDC80 kinetochore complex component homolog Antibody NUF2, S. cerevisiae, homolog of Antibody NUF2R Antibody NUF2_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.