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Anti-CDC25B Antibody

品牌：Antibodies

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规格：100µl

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Anti-CDC25B Antibody

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Overview

Name:	Anti-CDC25B Antibody See all CDC25B primary antibodies
Description:	Rabbit polyclonal antibody to CDC25B
Specificity:	The antibody detects endogenous levels of total CDC25B protein.
Applications:	WB, IHC
Dilutions:	Western blotting: 1:200-1:1000 Immunohistochemistry: 1:50-1:200
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human cell division cycle 25B
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
Sequence Similarities:	Belongs to the MPI phosphatase family.
Post-Translational Modification:	Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
Cellular Location:	Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle pole.
Database Links:	Entrez Gene: 994?Human Entrez Gene: 12531?Mouse Omim: 116949?Human SwissProt: P30305?Human SwissProt: P30306?Mouse Unigene: 153752?Human Unigene: 38444?Mouse
Synonyms:	AI604853 Antibody Cdc 25B Antibody Cdc25B Antibody CDC25HU2 Antibody Cdc25m2 Antibody Cell division cycle 25 homolog B Antibody Cell division cycle 25B Antibody Cell division cycle 25B isoform 1 Antibody Cell division cycle 25B isoform 2 Antibody Cell division cycle 25B isoform 3 Antibody Cell division cycle 25B isoform 4 Antibody Cell division cycle 25B isoform 5 Antibody Dual specificity phosphatase Cdc25B Antibody EC 3.1.3.48 Antibody M phase inducer phosphatase 2 Antibody M-phase inducer phosphatase 2 Antibody MPIP2_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.